Seokjoong Kim

The paper uses lineage tracing to show that fate restriction in mouse embryos and stem cell-derived models is asynchronous and not solely determined by cell identity.

This study corrects an ABCD1 mutation in ALD patient-derived iPSCs using CRISPR/Cas9 and homology-directed repair, restoring normal protein expression but not fully correcting metabolic issues.

DeepSpCas9 predicts SpCas9 activity across 12,832 target sequences with high generalization performance using deep learning.

The paper develops a method to enrich genome-edited human pluripotent stem cells by inducing temporary drug resistance through SLC35F2 knockdown, achieving efficient selection in 3 weeks.