Author

David William Will

European Molecular Biology Laboratory

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Assay:proteomics· 1 Approach:statistical model· 1 Approach:wet-lab / biochemical assay· 1

Frequent Co-Authors

Agnes SchröderiD· 1 shared Andreas Ulrich LindneriD· 1 shared Anil AkbaliD· 1 shared Annika Frauenstein· 1 shared Anushka KudaliyanageiD· 1 shared Benedikt O. GanseniD· 1 shared Dagmar WachteniD· 1 shared Daniel F. LegleriD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCell Biology

Agnes SchröderORCID

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2 papers

Recent·Most cited

Electrostatic interactions compensate energetic frustration in the coupled folding and binding of intrinsically disordered proteins

Lucı́a Álvarez, Nicolás A. Garrone, Michaël Claron, Kristian Schweimer, Juliana Glavina, David William Will, Peter A. Sehr, Joe Lewis, Toby J. Gibson, Ignacio Enrique Sanchez, Janosch Hennig, Lucia Beatriz Chemes

The paper investigates the energy landscape of coupled folding and binding in intrinsically disordered proteins, finding that electrostatic interactions compensate for energetic frustration.

bioRxiv · Jun 23, 2026 · PreprintBiophysics

NLRP3 activators disrupt the endocytic AP2 complex and plasma membrane signaling

Stefan Ebner, Kshiti Meera Phulphagar, Yubell Alvarez, Lars Jürgenliemke, Fabian Frechen, Isabel Stötzel, Marta Lovotti, Matthew Mangan, Anil Akbal, Niels Schneberger, Annika Frauenstein, Tabea Klein, Jonathan J. Swietlik, Benedikt O. Gansen, Diana Fink, , Felix Meissner

The paper shows NLRP3 activators disrupt the AP2 complex and impair plasma membrane signaling, leading to inflammation and cell death.

bioRxiv · Feb 25, 2026 · PreprintCell Biology