YAP/TEAD drives treatment-induced adaptive immunosuppression in EGFR-mutant lung cancer
Meija Honkanen, Jonas Baumgarten, Nikol Dibus, Jenna H. Rannikko, Miloš Gojković, Paloma Cejas, Yingtian Xie, Zsuzsanna Ortutay, Johannes A. M. Merilahti, Mari Tienhaara, Iman Khani Farahani, Steffen Boettcher, Pasi Antero Janne, Otto Kauko, Raphael A. Nemenoff, , Kari J. Kurppa
This study shows that DTP cells in EGFR-mutant lung cancer drive immunosuppression through YAP/TEAD activity, and co-targeting YAP/TEAD improves EGFR TKI therapy efficacy.
bioRxiv · Jan 24, 2026 · PreprintCancer Biology