Author

Tobias Ackermann

Amsterdam UMC Location University of AmsterdamORCID 0000-0002-9982-8697Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

Alejandro Huerta UribeiD· 1 shared Alexander CollingsiD· 1 shared Anand ManoharaniD· 1 shared Christina HalseyiD· 1 shared David O’ConnoriD· 1 shared David P. SumptoniD· 1 shared Ekaterini HimonasiD· 1 shared Engy ShokryiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

Alejandro Huerta UribeORCID

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1 paper

Recent·Most cited

Thiol Scarcity in Cerebrospinal Fluid Renders Leptomeningeal Acute Lymphoblastic Leukaemia Therapeutically Vulnerable to Ferroptosis

Nikolai Gajic, Rhona Christie, Shirley Lam, Tobias Ackermann, Ekaterini Himonas, Jonathan Josephs‐Spaulding, Anand Manoharan, Victoria D Assmann, Jordan Martin, Alexander Collings, Karen M. Dunn, Engy Shokry, Alejandro Huerta Uribe, Sharon Burns, David O’Connor, , Christina Halsey

This paper identifies a metabolic vulnerability in leptomeningeal ALL cells due to thiol scarcity in CSF, making them susceptible to ferroptosis through disruption of selenocysteine biosynthesis and GPX4 activity.

bioRxiv · Dec 17, 2025 · PreprintCancer Biology