Author

Karen M. Dunn

University of GlasgowORCID 0000-0002-6532-970XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

G. Vignir HelgasoniD· 2 shared Alastair SmithiD· 1 shared Alejandro Huerta UribeiD· 1 shared Alexander CollingsiD· 1 shared Alexander Winton· 1 shared Alexandra Curran· 1 shared Anand ManoharaniD· 1 shared Anindita RoyiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersCancer Biology

G. Vignir HelgasonORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

CD180 identifies chemoresistant stem-like blasts and reveals a KMT2A-driven vulnerability in acute myeloid leukaemia

Madonna M. Eltoukhy, Alexander Winton, Francesca Fasanella Masci, Elżbieta Kania, Mary T. Scott, Alastair Smith, Evie Rigby, Alexandra Curran, Aya Gouma, Jennifer E. Cassels, Lijun Liu, Thomas Stevens, Karen M. Dunn, Kevin M. Rattigan, Meaad almowaled, , Karen Keeshan

This paper identifies CD180 as a marker for chemoresistant stem-like blasts in KMT2A-rearranged paediatric AML, showing its absence on normal HSCs and its role as a therapeutic target.

bioRxiv · Apr 27, 2026 · PreprintCancer Biology

Thiol Scarcity in Cerebrospinal Fluid Renders Leptomeningeal Acute Lymphoblastic Leukaemia Therapeutically Vulnerable to Ferroptosis

Nikolai Gajic, Rhona Christie, Shirley Lam, Tobias Ackermann, Ekaterini Himonas, Jonathan Josephs‐Spaulding, Anand Manoharan, Victoria D Assmann, Jordan Martin, Alexander Collings, Karen M. Dunn, Engy Shokry, Alejandro Huerta Uribe, Sharon Burns, David O’Connor, , Christina Halsey

This paper identifies a metabolic vulnerability in leptomeningeal ALL cells due to thiol scarcity in CSF, making them susceptible to ferroptosis through disruption of selenocysteine biosynthesis and GPX4 activity.

bioRxiv · Dec 17, 2025 · PreprintCancer Biology