Arne Sahm

The Greenland shark (Somniosus microcephalus) genome provides insights into extremelongevity

The paper presents a chromosome-level genome assembly of the Greenland shark and identifies genomic features associated with its extreme longevity.

The HPA stress axis shapes aging rates in long-lived, social mole-rats

The paper investigates how the HPA stress axis influences aging in long-lived mole-rats, finding that reproductive status affects stress regulation and lifespan.

Dissecting the DNA binding landscape and gene regulatory network of p63 and p53

The paper identifies p63 binding sites and predicts its gene regulatory network using ChIP-seq data and motif analysis, highlighting potential therapeutic targets in SCC.

Higher transcriptome stability during aging in long-lived giant mole-rats compared to short-lived rats

This study compares transcriptome stability during aging between long-lived giant mole-rats and short-lived rats, finding greater stability in mole-rats.

Species comparison of liver proteomes reveals links to naked mole-rat longevity and human aging.

The paper compares liver proteomes of long-lived naked mole-rats and short-lived guinea pigs to identify molecular networks linked to longevity and human aging.

Naked mole-rat transcriptome signatures of socially-suppressed sexual maturation and links of reproduction to aging

The paper compares transcriptomes of breeders and non-breeders in naked mole-rats and guinea pigs to show socially suppressed sexual maturation and links between reproduction and aging.

Convergent evolution of genes controlling mitonuclear balance in annual fishes

The paper identifies genes under positive selection in annual African killifishes that are involved in mitonuclear balance, showing convergent evolution in four of five steps related to short lifespan and annual life cycle.