Lukáš Prchal

This study synthesizes and evaluates 4-(hexyloxy)benzoate derivatives to optimize muscarinic receptor antagonists, finding that rigid groups increase affinity but reduce duration, while flexible analogues balance potency and residence time.

This paper develops a novel NMDA receptor open-channel blocker, K2060, showing improved efficacy and reversibility compared to existing drugs like memantine and dizocilpine.

This study develops novel NMDA receptor antagonists with neuroprotective effects and reduced psychomimetic side effects through structural modifications of MK-801.

This study develops multi-target directed ligands (MTDLs) by modifying amiridine, a cholinesterase inhibitor, to enhance its therapeutic potential for Alzheimer's disease.