Ondřej Soukup

This study shows that HSD10 overexpression causes cytotoxicity linked to mitochondrial damage, and this effect is worsened by Aβ-rich environments, with inhibitors showing potential therapeutic benefit.

This paper develops a novel NMDA receptor open-channel blocker, K2060, showing improved efficacy and reversibility compared to existing drugs like memantine and dizocilpine.

This study develops novel NMDA receptor antagonists with neuroprotective effects and reduced psychomimetic side effects through structural modifications of MK-801.

This study evaluates dual-action tacrine derivatives as cholinesterase inhibitors and NMDA receptor antagonists for pro-cognitive effects in Alzheimer's disease models.

This study develops multi-target directed ligands (MTDLs) by modifying amiridine, a cholinesterase inhibitor, to enhance its therapeutic potential for Alzheimer's disease.