Author

Jakub Fibigar

University Hospital Hradec KrálovéORCID 0000-0002-5170-3668Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Organism:human· 1

Frequent Co-Authors

Anna MisiachnaiD· 2 shared Jan KorábečnýiD· 2 shared Martin HořákiD· 2 shared Tomas Kucera· 2 shared Emily LangoreiD· 1 shared Eva MezeiováiD· 1 shared Jakub NetolickýiD· 1 shared Jiří JanoušekiD· 1 shared

Activity by Year

2024-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersNeuroscience

Anna MisiachnaORCID

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2 papers

Recent·Most cited

Morphing Cholinesterase Inhibitor Amiridine into Multipotent Drugs for the Treatment of Alzheimer's Disease

Eva Mezeiová, Lukáš Prchal, Martina Hrabinová, Ľubica Múčková, Lenka Pulkrabkova, Ondřej Soukup, Anna Misiachna, Jiří Janoušek, Jakub Fibigar, Tomas Kucera, Martin Hořák, Галина Ф. Махаева, Jan Korábečný

This study develops multi-target directed ligands (MTDLs) by modifying amiridine, a cholinesterase inhibitor, to enhance its therapeutic potential for Alzheimer's disease.

Biomedicine & Pharmacotherapy · Mar 15, 2024Peer-reviewedNeuroscience

Independent regulation of early trafficking of NMDA receptors by ligand-binding domains of the GluN1 and GluN2A subunits

Jakub Netolický, Petra Zahumenska, Anna Misiachna, Marharyta Kolcheva, Tomas Kucera, Jakub Fibigar, Kristyna Rehakova, Katarína Hemelíková, Štěpán Kortus, Emily Langore, Marek Ladislav, Jan Korábečný, Martin Hořák

This study shows that structural changes in the ligand-binding domains of GluN1 and GluN2A subunits independently regulate early trafficking of NMDARs and that surface expression does not always correlate with agonist sensitivity.

bioRxiv · Feb 2, 2024 · PreprintNeuroscience