Alain J. van Gool

Dissecting the sources of variation in neuronally differentiated iPSC lines through multi-omics analysis

The paper identifies major sources of variability in iPSC-derived neurons and shows how correcting these improves disease signature detection.

Comprehensive multi-omics profiling of a healthy human cohort

The paper presents a comprehensive multi-omics dataset of healthy individuals, revealing sex and age influences and providing reference ranges for omics features.

Multi-omics Quality Assessment in Personalized Medicine through EATRIS

The paper describes EATRIS activities for quality assessment in multi-omics data generation and integration, aiming to support translational medicine through a Multi-Omics Toolbox.

Plasma glycoproteomics delivers high-specificity disease biomarkers by detecting site-specific glycosylation abnormalities

The paper develops a plasma N-glycoproteomics method to identify high-specificity disease biomarkers by detecting site-specific glycosylation abnormalities in genetic diseases.

A Multi-omics Data Analysis Workflow Packaged as a FAIR Digital Object

The paper develops a multi-omics data analysis workflow packaged as a FAIR Digital Object to improve reproducibility and reuse in computational research.

The GlycoPaSER prototype as a real-time N-glycopeptide identification tool based on the PaSER parallel computing platform

The paper introduces GlycoPaSER, a real-time glycopeptide identification tool that decomposes spectra and uses specialized algorithms for real-time analysis, matching performance with existing software.

Metabolic predictors of phenotypic traits can replace and complement measured clinical variables in transcriptome-wide association studies

This study evaluates metabolic predictors as alternatives to clinical variables in TWAS, finding they yield similar results and can complement incomplete phenotypic data.

Common variants associated with OSMR expression contribute to carotid plaque vulnerability, but not to cardiovascular disease in humans

The paper identifies a genetic variant associated with increased carotid plaque vulnerability but not with cardiovascular disease risk in humans.