Pirkko Mattila

GLE1 dysfunction compromises cellular homeostasis, spatial organization, and peripheral axon branching

This study investigates the role of GLE1 in cellular homeostasis and development, showing that its dysfunction leads to embryonic lethality and mid-adulthood death in mice, with defects in neural crest-derived tissues and stress responses.

Comprehensive multi-omics profiling of a healthy human cohort

The paper presents a comprehensive multi-omics dataset of healthy individuals, revealing sex and age influences and providing reference ranges for omics features.

Multi-omics Quality Assessment in Personalized Medicine through EATRIS

The paper describes EATRIS activities for quality assessment in multi-omics data generation and integration, aiming to support translational medicine through a Multi-Omics Toolbox.

Quartet RNA reference materials and ratio-based reference datasets for reliable transcriptomic profiling

The paper introduces RNA reference materials and ratio-based datasets to improve the reliability and benchmarking of transcriptomic profiling.

Analysis of human brain tissue derived from DBS surgery

The paper describes a method to collect brain tissue from DBS surgical instruments for transcriptomic and proteomic analysis, showing it provides reliable data comparable to traditional brain tissue samples.

Patient-tailored design of AML cell subpopulation-selective drug combinations

This paper develops a computational-experimental approach to design patient-specific drug combinations for AML that are synergistic and minimally toxic.