John D. Chan

This study compares the antischistosomal effects of antimalarials and TRP agonists using RNA-seq and efficacy tests in mice, finding distinct transcriptional responses and retained activity against praziquantel-resistant parasites.

This study investigates the transcriptional effects of meclonazepam on Schistosoma mansoni, showing it causes tegument damage and apoptosis, with gene expression patterns similar to but distinct from praziquantel.

This paper develops non-sedating antischistosomal benzodiazepines by modifying meclonazepam's structure, identifying compounds effective in vivo with reduced sedation.