Chao Liu

The paper shows Pseudomonas aeruginosa uses a CRISPR-Cas system to silence a proline-codon toxin that stops phage growth, revealing a defense mechanism against anti-CRISPR phages.

This study shows CRISPR-Cas regulates diverse anti-phage systems via crlRNAs, balancing their expression to prevent autoimmunity and enhance anti-phage defense.

Spateo provides a framework for spatiotemporal modeling of single-cell spatial transcriptomics data to study cell-cell interactions and organ development in 3D space.