Author

Thomas A. Guilliam

Nuclera (United Kingdom)ORCID 0000-0003-0065-2693Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Organism:non-human primate· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Agata K Jakimowicz· 1 shared Aidan J. DohertyiD· 1 shared Alastair CrispiD· 1 shared Dimitri Y. ChirgadzeiD· 1 shared Giulia ParisiD· 1 shared Guillaume GuilbaudiD· 1 shared Julian E. SaleiD· 1 shared Lee R. CooperiD· 1 shared

Activity by Year

2018-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperBiochemistry

Agata K Jakimowicz

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2 papers

Recent·Most cited

BiochemistrybioRxivPreprintOct 23, 2026

Rapid Production and Cryo-EM Structure Determination of GPCR-Nanodisc Complexes via Cell-Free Synthesis

Thomas A. Guilliam, Agata K Jakimowicz, Marco M. Manni…·Tobias WB Ost

This paper presents a cell-free method to rapidly produce and determine cryo-EM structures of GPCR-nanodisc complexes, achieving structural-grade results in four days.

DOI 10.64898/2026.10.21.760646

humanprotein structure

𝕏 PostBluesky

Molecular BiologyThe EMBO JournalPeer-reviewedNov 26, 2018

S phase R-loop formation is restricted by PrimPol-mediated repriming

Saša Šviković, Alastair Crisp, Sue Mei Tan‐Wong…·Julian E. Sale

The paper shows that PrimPol-mediated repriming limits R-loop formation during S phase, preventing replication blocks at susceptible sequences.

100 citationstop 4%

humannon-human primate

𝕏 PostBluesky