Guillaume Guilbaud

This study shows that DNA replication initiation sites drive mutagenesis and genomic rearrangements in cancers by affecting repair processes and mutational patterns.

The paper maps human DNA replication origins and their efficiency, showing hierarchical organization within initiation zones.

This study shows that replication origins in humans increase mutation rates and influence gene expression and mRNA isoform usage through mutagenic processes during DNA replication.

The paper shows that PrimPol-mediated repriming limits R-loop formation during S phase, preventing replication blocks at susceptible sequences.

The paper investigates X-linked gene reactivation in mouse inner cell mass by analyzing epigenetic marks and transcription factors, finding differential reactivation speeds and mechanisms.