Author

Aidan J. Doherty

University of SussexORCID 0000-0002-6370-1109Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:DNA methylation· 2 Research Focus:gene regulatory network inference· 2 Research Focus:cell-cell communication· 1 Organism:non-human primate· 1 Research Focus:variant calling· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Laura J. BaileyiD· 2 shared Akhil BowryiD· 1 shared Alastair CrispiD· 1 shared Alexandra K. Walker· 1 shared Ann Liza Piberger· 1 shared Daniel González‐AcostaiD· 1 shared Eva PetermanniD· 1 shared Guillaume GuilbaudiD· 1 shared

Activity by Year

2018-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersMolecular Biology

Laura J. BaileyORCID

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Author profile →

3 papers

Recent·Most cited

PrimPol-dependent single-stranded gap formation mediates homologous recombination at bulky DNA adducts

Ann Liza Piberger, Akhil Bowry, Richard D. Kelly, Alexandra K. Walker, Daniel González‐Acosta, Laura J. Bailey, Aidan J. Doherty, Juan Méndez, Joanna R. Morris, Helen E. Bryant, Eva Petermann

This study shows that PrimPol creates single-stranded gaps at bulky DNA adducts, which recruit RAD51 for homologous recombination, facilitating DNA repair in mammalian cells.

Nature Communications · Nov 17, 2020Peer-reviewedMolecular Biology

PrimPol is required for the maintenance of efficient nuclear and mitochondrial DNA replication in human cells

Laura J. Bailey, Julie Bianchi, Aidan J. Doherty

This study shows that PrimPol is essential for efficient nuclear and mitochondrial DNA replication in human cells, preventing fork stalling and mutations even without exogenous damage.

Nucleic Acids Research · Jan 28, 2019Peer-reviewedGenetics

S phase R-loop formation is restricted by PrimPol-mediated repriming

Saša Šviković, Alastair Crisp, Sue Mei Tan‐Wong, Thomas A. Guilliam, Aidan J. Doherty, Nicholas J. Proudfoot, Guillaume Guilbaud, Julian E. Sale

The paper shows that PrimPol-mediated repriming limits R-loop formation during S phase, preventing replication blocks at susceptible sequences.

The EMBO Journal · Nov 26, 2018Peer-reviewedMolecular Biology