Author

Frances K. Shepherd

University of MinnesotaORCID 0000-0002-9792-5805Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Organism:chicken / avian· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Ryan Andrew LangloisiD· 3 shared Adam J. GilbertseniD· 2 shared Cera A. McDonaldiD· 2 shared Clayton K. MickelsoniD· 2 shared Jordan T. BeckeriD· 2 shared Lauren M. ProssiD· 2 shared Mark J. PiersoniD· 2 shared Alberto Moreno· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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3 shared papersImmunology

Ryan Andrew LangloisORCID

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3 papers

Recent·Most cited

A mammalian fibroblast zoo reveals barriers to cross-species virus replication and differential regulation of antiviral immunity

Clayton K. Mickelson, Mark Salnikov, Frances K. Shepherd, Lauren M. Pross, Georgia McClain, Swechha Mainali Pokharel, H. Heinrich Hoffmann, Timo Schoon, Girish Pulinkala, Nakarin Pamornchainavakul, Kayla Hoffman, Cera A. McDonald, Esther Vogt, Tristan T. Neal, Adam J. Gilbertsen, , Ryan A. Langlois

The paper uses fibroblasts from 86 mammalian species to study virus-host susceptibility and innate immune responses across diverse mammals.

bioRxiv · Nov 6, 2026 · PreprintImmunology

Dirty mice better recapitulate key features of mRNA vaccine immunogenicity observed in humans

Beatriz Praena, Frances K. Shepherd, Cera A. McDonald, Devyani Joshi, Sneh Lata Gupta, Madison L Ellis, Lilin Lai, Alberto Moreno, Shanley N. Roach, Mark J. Pierson, Adam J. Gilbertsen, Carl W. Davis, Mehul S. Suthar, Jens Wrammert, Ryan Andrew Langlois

This study shows that dirty mice, with broad microbial exposure, better model human immune responses to SARS-CoV-2 mRNA vaccines, showing reduced antibody titers and faster waning compared to SPF mice.

mBio · Jul 6, 2026Peer-reviewedImmunology

Mammalian ZAP and KHNYN can independently restrict CpG-enriched avian viruses

Jordan T. Becker, Clayton K. Mickelson, Lauren M. Pross, Autumn E. Sanders, Esther R. Vogt, Frances K. Shepherd, Chloe Wick, Alison J. Barkhymer, Stephanie L. Aron, Elizabeth J. Fay, Reuben S. Harris, Ryan Andrew Langlois

The paper shows mammalian ZAP and KHNYN can restrict CpG-enriched avian viruses, with human ZAP or KHNYN independently limiting CpG-enriched IAV in chicken and human cells.

PLoS Biology · Oct 28, 2025Peer-reviewedMicrobiology