Philip Brownridge

The paper evaluates proteomics platforms for metabolic pathway analysis in biomanufacturing chassis organisms, showing varying proteome coverage across different instruments.

This paper optimizes haemoglobin depletion in dried blood spots to improve proteomic analysis, increasing protein identifications by ~50% and enabling biomarker discovery in CKD patients.

This study examines proteomic changes in human muscle constructs under microgravity and shows that HSP10 overexpression reduces these changes, suggesting a potential strategy for combating muscle atrophy.

This paper introduces scpImaging, a computational pipeline that uses microscopy data to detect multiplets and improve quality control in single-cell proteomics.

The paper identifies zDHHC23 as a hypoxia-responsive gene associated with metastasis in non-MYCN amplified neuroblastoma, suggesting it as a potential biomarker and therapeutic target.

This study presents an optimized phosphoproteomics workflow using SP3 beads with improved phosphopeptide identification and detection of multiply phosphorylated peptides in HEK-293T cells.

Cryo-ET of 169 nm β-carboxysomes from low-light Synechococcus elongatus reveals ~639 Rubiscos in concentric layers with CcmM bound at RbcL grooves; QconCAT proteomics yields the complete absolute protein stoichiometry.

This study identifies PNUTS-PP1 as a regulator of Cdk11 phosphorylation, showing that dephosphorylation by PNUTS-PP1 modulates Cdk11 activity and affects mRNA processing and splicing.

This study investigates pseudogene expression in Sodalis glossinidius using multi-omic approaches, revealing significant transcriptional activity and suggesting their role in evolutionary adaptation.