Mark F. Coughlin

This study develops an optical system to measure perfusion pressure and flow resistance in microfluidic devices without contacting the fluid, validating its accuracy against hydrostatic methods.

This study generates functional endothelial cells from human iPSCs using ETV2 overexpression, enabling the creation of vascularized microphysiological models.

This study shows that long-term flow can maintain and remodel microvascular networks in a microphysiological system for 51 days, reducing inflammation and enabling vascular remodeling.

This paper develops a vascularized tumor model to study TAM recruitment and evaluates a multispecific antibody's effect on monocyte migration and TAM repolarization.