Roger Dale Kamm

A mechanically actuated lung microvascular model reveals that breathing-like deformation enhances tumor cell extravasation

IntravChip: a vascularized and perfused microfluidic model of the primary tumor microenvironment to collect intravasated tumor cells

The paper introduces IntravChip, a microfluidic platform to study tumor cell intravasation and collect intravasated cells, showing it can quantify intravasation rates and test anti-metastatic drugs.

4D force patterning enables spatial control of angiogenesis

This paper demonstrates that 4D force patterning using a magnetically actuated vessel-on-a-chip platform enables precise spatiotemporal control over angiogenesis by modulating mechanical strain magnitude, frequency, and direction.

ETV2 mediated differentiation of human pluripotent stem cells results in functional endothelial cells for engineering advanced vascularized microphysiological models

This study generates functional endothelial cells from human iPSCs using ETV2 overexpression, enabling the creation of vascularized microphysiological models.

miR126-mediated impaired vascular integrity in Rett syndrome

This study investigates vascular impairment in Rett syndrome by analyzing patient-derived endothelial cells and identifies miR126-3p as a mediator of vascular dysfunction.

A Vascularized Liver Microphysiological System Captures Key Features of Hepatic Insulin Resistance and Monocyte Infiltration

This paper develops a vascularized liver microphysiological system to model hepatic insulin resistance and monocyte infiltration, showing altered metabolism, vascular changes, and immune cell recruitment.

Myofibroblasts reduce angiogenesis and vasculogenesis in a vascularized microphysiological model of lung fibrosis

The paper develops a microphysiological model of lung fibrosis to study myofibroblast-vascular interactions, finding that myofibroblasts reduce angiogenesis and vasculogenesis through TGF-β1 and reduced VEGF.

A novel human blood-brain barrier model reveals pericytes as critical regulators of viral neuroinvasion

This study develops a human BBB model using NCC-PCs to show they protect against viral neuroinvasion by maintaining BMEC barrier integrity.

Remodeling of self-assembled microvascular networks under long term flow

This study shows that long-term flow can maintain and remodel microvascular networks in a microphysiological system for 51 days, reducing inflammation and enabling vascular remodeling.

3D printing and bioprinting for miniaturized and scalable hanging-drop organoids culture

This paper develops a bioprinting system for miniaturized hanging-drop organoid cultures in sBME, improving scalability and reproducibility for high-throughput applications.

Polyploidy of MDA-MB-231 cells drives increased extravasation with enhanced cell-matrix adhesion

This study shows that polyploidy in MDA-MB-231 breast cancer cells increases extravasation through enhanced cell-matrix adhesion.

A high-throughput 3D culture microfluidic platform for multi-parameter phenotypic and omics profiling of patient-derived organoids

This paper introduces a high-throughput microfluidic platform for organoid culture and multi-omics profiling, demonstrating its utility in clinical and drug discovery settings.