Lutz Brusch

FitMultiCell provides a scalable pipeline for modeling, simulating, and parameterizing multi-scale multi-cellular processes using Morpheus and pyABC.

The paper investigates how collective cell migration is robust to different integration strategies of guidance stimuli using an individual-based model.

The paper shows that polster cells in zebrafish gastrulation are guided by their follower cells through mechanotransduction, enabling long-range coordination of migration.

The paper investigates how the acto-myosin system regulates YAP activity during liver regeneration in response to bile acid overload.

The paper develops a probabilistic model to accurately estimate cell proliferation rates from continuous labeling assays, accounting for biological variability and showing current methods can be biased.

This study investigates multi-scale coordination of planar cell polarity in planarians, identifying core pathways that mediate global polarization fields.