BiochemistrybioRxivPreprint
Uridine-sensitized screening identifies genes and metabolic regulators of nucleotide synthesis
Abigail Strefeler, Zakery N. Baker, Sylvain Chollet…·Alexis A. Jourdain
The paper identifies genes and metabolic regulators of nucleotide synthesis using uridine salvage and CRISPR-Cas9 screening, revealing NUDT5's role in maintaining nucleotide balance and its impact on chemotherapy resistance.
6 citations