BioengineeringbioRxivPreprint
GPCR Antagonism via Antibody-Mediated Rewiring of Receptor Trafficking and Degradation
Kaitlin Rhee, Lawrence Shue, Akimasa Adachi…·Xin X. Zhou
This paper introduces GTACs, bispecific antibodies that selectively downregulate GPCRs via endocytosis and lysosomal degradation, showing high potency and selectivity for therapeutic targets.
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