Author

Lawrence Shue

Harvard UniversityORCID 0000-0003-4525-9270Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Assay:proteomics· 1

Frequent Co-Authors

Dingjingyu Zhou· 2 shared Xin X. ZhouiD· 2 shared Akimasa AdachiiD· 1 shared Andrew C. KruseiD· 1 shared Aoxing ChengiD· 1 shared Apoorva BaluapuriiD· 1 shared Edward P. HarveyiD· 1 shared Eric S. FischeriD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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2 shared papersBioengineering

Dingjingyu Zhou

Mutual co-authors in cluster

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2 papers

Recent·Most cited

BioengineeringbioRxivPreprintMay 10, 2026

Z-TAC enables custom and combinatorial degradation of cell surface proteins

Dingjingyu Zhou, Lawrence Shue, Sean H Gao…·Xin X. Zhou

Z-TAC converts IgG antibodies into cell-surface protein degraders, enabling efficient and sustained degradation of multiple receptors and receptor combinations.

1 citation

experimental assaydrug response / drug discovery

𝕏 PostBluesky

BioengineeringbioRxivPreprintAug 8, 2025

GPCR Antagonism via Antibody-Mediated Rewiring of Receptor Trafficking and Degradation

Kaitlin Rhee, Lawrence Shue, Akimasa Adachi…·Xin X. Zhou

This paper introduces GTACs, bispecific antibodies that selectively downregulate GPCRs via endocytosis and lysosomal degradation, showing high potency and selectivity for therapeutic targets.

2 citations

proteomicsexperimental assay

𝕏 PostBluesky