Paweł Pelczar

This paper introduces CTM-nSeq, a method for targeted long-read sequencing using Cas12a and nanopore technology, achieving high coverage and multiplexing capabilities.

This study shows that expressing two linker proteins in mouse models of LAMA2-related muscular dystrophy improves muscle function and prevents hindlimb paralysis.

The paper shows that glial activation in prion diseases is nonautonomous, requiring neuronal PrPSc to drive neural dysfunction.

The paper identifies boundary sequences at the mouse tyrosinase locus that act as enhancers and insulators, preventing cross-talk with adjacent genes.

The paper uses TRAP to analyze translatomes of excitatory and inhibitory neurons in mouse spinal cords, finding neuropeptide genes associated with modality-specific processing and showing little translatome change in neuropathic pain.

This paper develops a method for high fidelity lineage tracing in mouse pre-implantation embryos using primed conversion of photoconvertible proteins and light-sheet imaging.

The paper shows that alterations in sperm long RNA contribute to the inheritance of trauma-induced behavioral and metabolic effects.