Author

Shiyun Xiao

University of GeorgiaORCID 0000-0003-0196-287XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Assay:CITE-seq· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Nancy Ruth ManleyiD· 4 shared Jie LiiD· 2 shared Kimberly D. KlonowskiiD· 2 shared Wen ZhangiD· 2 shared Brian G. CondieiD· 1 shared Colleen J. SedneyiD· 1 shared Disha BR PrasadiD· 1 shared Edward L.Y. CheniD· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersImmunology

Nancy Ruth ManleyORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

ImmunologyThe Journal of ImmunologyPeer-reviewedMar 1, 2026

Adult mice with neonatal-like T cell subsets exhibit increased susceptibility to Bordetella pertussis and influenza infection

Matthew R. Hansen, Colleen J. Sedney, Shiyun Xiao…·Nancy Ruth Manley

This study shows that adult mice with neonatal-like T cell subsets are more susceptible to Bordetella pertussis but not influenza, highlighting the role of thymic development in immune responses.

DOI 10.1093/jimmun/vkaf361

mouseCITE-seq

𝕏 PostBluesky

ImmunologyThe Journal of ImmunologyPeer-reviewedAug 18, 2025

Premature thymic involution in young Foxn1lacz mutant mice causes peripheral T cell phenotypes similar to aging-induced immunosenescence

Shiyun Xiao, Seungwoo Kang, Kimberly Oliva…·Nancy Ruth Manley

8 citations

mousebulk RNA-seq

𝕏 PostBluesky

Developmental BiologyDevelopmentPeer-reviewedMar 28, 2023

Foxn1 overexpression promotes thymic epithelial progenitor cell proliferation and mTEC maintenance, but does not prevent thymic involution

Jie Li, Lucas P. Wachsmuth, Shiyun Xiao…·Nancy Ruth Manley

This study shows Foxn1 overexpression in TECs promotes proliferation and differentiation but does not prevent aging-related thymic involution.

20 citations

mouseexperimental assay

𝕏 PostBluesky

Developmental BiologyDevelopmentPeer-reviewedJan 1, 2020

NOTCH1 signaling establishes the medullary thymic epithelial cell progenitor pool during mouse fetal development

Jie Li, Julie Gordon, Edward L.Y. Chen…·Nancy Ruth Manley

This study shows Notch1 signaling is essential for specifying and expanding the medullary thymic epithelial cell (mTEC) progenitor pool during mouse fetal development.

31 citations

mouseexperimental assay

𝕏 PostBluesky