Wen Zhang

Ourotide: decoding the hierarchical peptide recognition for generative design

The paper introduces Ourotide, a deep learning framework for peptide recognition that outperforms generalist models by capturing a unique hierarchical binding mode through physics-guided data augmentation.

Adult mice with neonatal-like T cell subsets exhibit increased susceptibility to Bordetella pertussis and influenza infection

This study shows that adult mice with neonatal-like T cell subsets are more susceptible to Bordetella pertussis but not influenza, highlighting the role of thymic development in immune responses.

Geoclimatic oscillations and ancient reciprocal adaptive introgression shape the evolutionary trajectories of threatened Coilia

This study reconstructs the evolutionary history of Coilia species, revealing ancient reciprocal introgression and its role in adaptation to geoclimatic changes.

stGCL: A versatile cross-modality fusion method based on multi-modal graph contrastive learning for spatial transcriptomics

stGCL integrates multi-modal spatial transcriptomics data using graph contrastive learning to improve clustering and spatial pattern analysis.

Psilocybin Promotes Cell-Type-Specific Changes in the Orbitofrontal Cortex Revealed by Single-Nucleus RNA-seq

This study uses single-nucleus RNA-seq to show psilocybin induces cell-type-specific genetic and functional changes in the orbitofrontal cortex neurons.

Pan-cancer tumor classification by a holistic tumor microenvironment atlas

This paper develops a pan-cancer tumor classification system based on tumor microenvironment cellular components, identifying immune-activation patterns and therapeutic response stratifications.

Premature thymic involution in young Foxn1lacz mutant mice causes peripheral T cell phenotypes similar to aging-induced immunosenescence

Age-Related Changes of Dopamine D1 and D2 Receptors Expression in Parvalbumin-Positive Cells of the Orbitofrontal and Prelimbic Cortices of Mice

Mapping genomic loci prioritises genes and implicates synaptic biology in schizophrenia

A genome-wide association study of 69,369 schizophrenia cases and 236,642 controls identifies 270 risk loci, prioritizes 130 genes, and links common and rare risk variants to neuronal synaptic biology.

Direct and Indirect Pathway Neurons in Ventrolateral Striatum Differentially Regulate Licking Movement and Nigral Responses

The paper investigates how D1 and D2 receptor-expressing medium spiny neurons in the ventrolateral striatum regulate licking behavior and nigral responses at different timescales.

The landscape of human brain immune response in patients with severe COVID-19

The paper analyzes single-nucleus transcriptomes from brain regions of COVID-19 patients to show increased neuroinflammation and microglial transcriptome changes, without evidence of viral brain tropism.

A Bayesian Framework for Multiple Trait Colocalization from Summary Association Statistics

This paper introduces a Bayesian framework to identify regulatory effects at GWAS risk loci by integrating GWAS summary data with molecular QTL data.