Ernest Arenas

This study identifies SorCS2 as a regulator of Wnt signaling homeostasis by controlling Ror2 trafficking and signaling, with implications for neurodevelopment.

The paper identifies strategies to prevent transgene silencing during human pluripotent stem cell differentiation and introduces a robust vector construct.

The paper develops a multi-omics guided differentiation protocol to generate PD-vulnerable midbrain dopaminergic neurons, showing improved yield and functional recovery in mice.

The paper identifies two distinct radial glia subtypes in the developing midbrain and shows their different roles in dopaminergic neuron development using human stem cells.

This study creates a comprehensive cell atlas of the first-trimester human brain using single-cell RNA sequencing and spatial transcriptomics, identifying over 600 distinct cell states and their spatial organization.

This study identifies 461 cell clusters and 3313 subclusters in the adult human brain using single-nucleus RNA sequencing, revealing regional diversity in neurons and astrocytes.

The paper identifies and characterizes a reference iPSC line, KOLF2.1J, for standardized use in collaborative studies across multiple differentiation protocols and assays.

This study improves human embryonic stem cell differentiation into midbrain dopaminergic neurons using specific factors and reveals developmental dynamics and high-quality cell types through single-cell RNA-sequencing.

The paper shows that early pre-neural serotonin in zebrafish affects later serotonin synthesis and behavioral patterns without causing major developmental abnormalities.

This study identifies the MEIS-WNT5A axis as critical for the development and morphology of the fourth ventricle choroid plexus.

The paper maps cell types in the mouse nervous system using single-cell RNA sequencing and identifies distinct astrocyte and oligodendrocyte subtypes with specific molecular and spatial characteristics.

The paper identifies three radial glia types contributing to midbrain dopaminergic neurogenesis through distinct developmental signals and transcription factor networks.