Holly E. Poore

This study identifies 1,294 genomic regions and 961 effector genes associated with externalizing disorders, revealing neural mechanisms and polygenic predictors of variance in these conditions.

This study identifies genetic relationships between substance use disorders and externalizing/internalizing psychopathology, finding that internalizing contributes uniquely to SUD risk.

This study identifies a genetic link between externalizing traits and suicide risk using genomic data and electronic health records from over 500,000 veterans.

This paper evaluates how down-sampling affects GWAS summary statistics and recommends reporting specific analyses to support their use.

This study uses Genomic Structural Equation Modeling to identify a common genetic factor underlying externalizing phenotypes and substance use disorders, finding that a single dimension of genetic risk best explains their relationships.

The paper uses multivariate genomic analysis of 1.5 million people to identify genetic loci related to addiction, antisocial behavior, and health, finding over 500 loci enriched for brain-expressed genes.

This study tests structural models of psychopathology using genetic correlations from GWAS, finding a four-factor model better fits the data than a bifactor model.