Laurent Maloisel

This study identifies an 85-residue segment of Rad52 that facilitates Rad51 filament formation and stability through structural and functional analyses in yeast.

This study shows the Rad55-Rad57 complex promotes Rad51 filament stability on UV-induced single-strand DNA gaps, counteracting error-prone polymerases to favor error-free homologous recombination.

The paper investigates how Rad52's N-terminal domain stabilizes Rad51 filaments and protects them from Srs2, showing that mutations in this domain reduce toxicity in Srs2-deficient cells.