Samuel Singleton

This study shows that pre-injury stress in male mice reduces pain symptoms in osteoarthritis, while increasing them in females, revealing sex-specific effects of stress on pain resilience.

This study shows that inhibiting FKBP51 early in joint pain reduces both sensory and emotional symptoms for up to 6 months, while late inhibition only provides temporary relief.

This study shows that sub-chronic stress causes hypomethylation of the Fkbp5 promoter, increasing chronic pain vulnerability, but reversing this methylation does not prevent pain.

The paper tests eCF506, a c-Src inhibitor, showing it reduces opioid tolerance by decreasing β-arrestin2 recruitment without affecting cAMP inhibition.