Author

James R. Byrnes

University of California, San FranciscoORCID 0000-0003-0297-1209Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Organism:Drosophila· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

James A. WellsiD· 2 shared Alissa L. NanaiD· 1 shared Ankit GuptaiD· 1 shared Brandon B. HolmesiD· 1 shared Brandon I. Apresa· 1 shared Bruce L. MilleriD· 1 shared Carlo CondelloiD· 1 shared Cassandra D. BelairiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersNeuroscience

James A. WellsORCID

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2 papers

Recent·Most cited

NeuroscienceMolecular NeurodegenerationPeer-reviewedAug 29, 2025

β-Amyloid Induces Microglial Expression of GPC4 and APOE Leading to Increased Neuronal Tau Pathology and Toxicity

Brandon B. Holmes, Thaddeus K. Weigel, Jesseca M. Chung…·James A. Wells

This study shows that β-amyloid induces microglial GPC4 and APOE, which increases neuronal tau pathology and toxicity.

11 citationstop 2%

humanDrosophila

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ImmunologyCancer Immunology ResearchPeer-reviewedApr 1, 2024

PVRL2 Suppresses Anti-tumor Immunity Through PVRIG- and TIGIT-Independent Pathways

Jiuling Yang, Li Wang, James R. Byrnes…·Robert H. Blelloch

This study shows PVRL2 suppresses anti-tumor immunity independently of PVRIG and TIGIT, with deletion reducing tumor growth more than PD-L1 loss.

14 citations

mouseexperimental assay

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