Ryosuke Kaneko

This paper develops a compact promoter for AAV gene therapy targeting inhibitory neurons, showing efficacy in treating epilepsy by restoring GABA function.

The paper develops cPcdhβ reporter mouse lines to visualize stochastic expression of cPcdhβ isoforms in vivo and identifies patterns such as cell-type selectivity and developmental regulation.

The paper visualizes homophilic interactions of clustered protocadherin in neurons using a novel FRET probe and finds that these interactions occur at contact sites between neurites and are stable, while synapses show rare homophilic interactions.