Borja Gomez Ramos

ZFHX4 is necessary for dopaminergic neuron differentiation and controls cell cycle by regulating LIN28A

This study identifies ZFHX4 as a key regulator of midbrain dopaminergic neuron differentiation by controlling cell cycle progression through the LIN28A-miR-9 axis.

Identification of Parkinson's disease-associated regulatory variants in human dopaminergic neurons reveals modulators of SCARB2 and BAG3 expression

The paper identifies Parkinson's disease-associated regulatory variants in human dopaminergic neurons and shows they modulate SCARB2 and BAG3 expression.

Active repression of cell fate plasticity by PROX1 safeguards hepatocyte identity and prevents liver tumourigenesis

The paper identifies PROX1 as a safeguard repressor that maintains hepatocyte identity and prevents liver tumourigenesis by repressing alternate fate regulators.

Multi-omics analysis identifies LBX1 and NHLH1 as central regulators of human midbrain dopaminergic neuron differentiation

SETD7-mediated lysine monomethylation is abundant on non-hyperphosphorylated nuclear Tau

The paper identifies lysine monomethylation on Tau by SETD7 in human brain tissue and shows its association with nuclear Tau in a mouse model of tauopathy.

A post-translational modification signature defines changes in soluble tau correlating with oligomerization in early stage Alzheimer’s disease brain

The paper identifies specific phosphorylation sites on soluble tau oligomers in early Alzheimer’s disease that differ from those in neurofibrillary tangles.