Haonan Lin

The paper uses SPEND-hSRS imaging to visualize fumarate in bladder cancer cells, revealing mitochondrial metabolic heterogeneity and interactions with lipid droplets.

This study shows that modulating cholesterol metabolism in ovarian cancer cells enhances CAR-T cell cytotoxicity by disrupting lipid storage mechanisms.

This paper introduces a mid-infrared photothermal mesoscope with millimeter-scale field of view and sub-micron resolution, enabling in vivo chemical imaging and Alzheimer's disease biomarker detection.

The paper identifies Wnt signaling defects and GSK3b overactivity as regulators of lipid accumulation in APOE4 oligodendrocytes, showing that inhibiting GSK3b reduces lipid droplets and improves myelination.

This study uses longitudinal single-cell chemical imaging to reveal fatty acid production heterogeneity in engineered E. coli strains over time.

The paper introduces a deep learning framework for automated cell segmentation, tracking, and lineage reconstruction in time-lapse microscopy data with high accuracy and speed.