Author

Adele Bubnys

Massachusetts Institute of Technology

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Assay:CRISPR screen· 1 Research Focus:database / resource· 1 Research Focus:differential expression· 1 Assay:electronic health records· 1

Frequent Co-Authors

Li‐Huei TsaiiD· 4 shared Alan Y. L. JiangiD· 3 shared Emre Agbas· 3 shared Alice E. StantoniD· 2 shared Colin Staab· 2 shared Joel BlanchardiD· 2 shared Leyla Anne AkayiD· 2 shared M KellisiD· 2 shared

Activity by Year

2019-2025 · peak 3/yr

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10 top collaborators · 41 mutual co-author links

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4 shared papersNeuroscience

Li‐Huei TsaiORCID

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5 papers

Recent·Most cited

Engineered 3D Immuno-Glial-Neurovascular Human miBrain Model

Alice E. Stanton, Adele Bubnys, Emre Agbas, Benjamin T. James, Dong Shin Park, Alan Y. L. Jiang, Rebecca L. Pinals, Liwang Liu, Nhat Truong, Anjanet R. Loon, Colin Staab, Oyku Cerit, Hsin-Lan Wen, David V. Mankus, Margaret E. Bisher, , Li‐Huei Tsai

The paper constructs a 3D human brain model integrating multiple cell types to study Alzheimer's Disease mechanisms linked to APOE4.

Proceedings of the National Academy of Sciences · Oct 17, 2025Peer-reviewedNeuroscience

Genome-wide CRISPR screen reveals Wnt signaling defects regulate lipid accumulation in APOE4 oligodendrocytes

Leyla Anne Akay, Anna Bright, Carles A. Boix, Kate Louderback, Janine A Medrano, Dingcheng Sun, Haonan Lin, Oisín King, Gwyneth Welch, Hiba Nawaid, Emre Agbas, Alan Y. L. Jiang, Adele Bubnys, Ji‐Xin Cheng, Joel Blanchard, Li‐Huei Tsai

The paper identifies Wnt signaling defects and GSK3b overactivity as regulators of lipid accumulation in APOE4 oligodendrocytes, showing that inhibiting GSK3b reduces lipid droplets and improves myelination.

bioRxiv · Oct 16, 2025 · PreprintNeuroscience

Vascular-Perfusable Human 3D Brain-on-Chip

Alice E. Stanton, Rebecca L. Pinals, Aaron Choi, Nhat Truong, Eulim Kang, Alan Y. L. Jiang, Claudia F. Lozano Cruz, Sydney Hawkins, Ryana Sarcar, Alexandra Volkova, Oisín King, Emre Agbas, Masayuki Nakano, Ching‐Chi Chiu, Adele Bubnys, , Li‐Huei Tsai

The paper develops a 3D Brain-Chip system using human iPSC-derived cells to model the BBB and study APOE4's role in Alzheimer's disease.

bioRxiv · Sep 18, 2025 · PreprintNeuroscience

Single-cell multi-region dissection of brain vasculature in Alzheimer's Disease

Na Sun, Leyla Anne Akay, Mitchell H. Murdock, Yongjin Park, Adele Bubnys, Kyriaki Galani, Hansruedi Mathys, Xueqiao Jiang, Ayesha P. Ng, David Alan Bennett, Li‐Huei Tsai, M Kellis

The paper identifies cell-type-specific molecular changes in cerebrovascular cells across brain regions in Alzheimer's Disease, linking them to genetic variants and potential therapeutic targets.

bioRxiv · Feb 9, 2022 · PreprintNeuroscience

Hindbrain V2a neurons impose rhythmic activity on motor neurons in an in vitro reticulospinal circuit

Adele Bubnys, Hagar Kandel, Lee‐Ming Kow, Donald W. Pfaff, Inna Tabansky

The paper demonstrates that Chx10+ hindbrain neurons can synchronize motor neurons in an in vitro reticulospinal circuit through AMPA receptor-dependent mechanisms.

Frontiers in Neuroscience · Oct 17, 2019Peer-reviewedNeuroscience