Author
Massachusetts Institute of TechnologyORCID 0000-0002-5944-2466Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
Recent·Most cited
Leyla Anne Akay, Anna Bright, Carles A. Boix…·Li‐Huei Tsai
The paper identifies Wnt signaling defects and GSK3b overactivity as regulators of lipid accumulation in APOE4 oligodendrocytes, showing that inhibiting GSK3b reduces lipid droplets and improves myelination.
Na Sun, Leyla Anne Akay, Mitchell H. Murdock…·M Kellis
The paper identifies cell-type-specific molecular changes in cerebrovascular cells across brain regions in Alzheimer's Disease, linking them to genetic variants and potential therapeutic targets.
Nader Morshed, William T. Ralvenius, Alexi Nott…·Forest M. White
The paper uses phosphoproteomics to identify Siglec-F and Siglec-8 as upregulated in microglia during neurodegeneration, driving inflammatory responses in mouse and human models.
Zhuyu Peng, Wen‐Chin Huang, Maggie Chen…·Li‐Huei Tsai
This study investigates the role of Cdk5 in microglia under physiological and pathological conditions, finding transcriptional changes but minimal effects on morphology and behavior.