Author

Takuma Kume

University of Wisconsin–MadisonORCID 0000-0003-0448-1991Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Saeed RoschdiiD· 2 shared Samuel E. ButcheriD· 2 shared Aaron A. HoskinsiD· 1 shared Abby A. McCanniD· 1 shared Anika Richard· 1 shared Cristian Escobar BravoiD· 1 shared M. Thomas RecordiD· 1 shared Rahul VivekiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

9 top collaborators · 24 mutual co-author links

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2 shared papersBiochemistry

Saeed RoschdiORCID

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2 papers

Recent·Most cited

BiochemistryNature CommunicationsPeer-reviewedAug 12, 2026

TDP-43 controls RNA structure through high affinity lattice interactions

Rahul Vivek, Takuma Kume, Saeed Roschdi…·Samuel E. Butcher

This study shows TDP-43 binds to GU repeats with high affinity, prevents pUG fold formation, and reveals an interplay between RNA folding and protein recognition.

1 citation

humanexperimental assay

𝕏 PostBluesky

BiochemistryRNA BiologyPeer-reviewedMar 3, 2026

Sequence and ionic requirements of pUG fold quadruplexes

Saeed Roschdi, Takuma Kume, Riley J. Petersen…·Samuel E. Butcher

This study identifies sequence and ionic requirements for pUG fold RNA quadruplexes, showing flexibility in nucleotide substitutions and specific ion dependence.

5 citationstop 2%

experimental assay

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