Author

Saeed Roschdi

University of Wisconsin–MadisonORCID 0000-0001-6360-6868Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 3 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:C. elegans· 2 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:database / resource· 1

Frequent Co-Authors

Samuel E. ButcheriD· 4 shared Rahul VivekiD· 3 shared Riley J. PeterseniD· 3 shared Cristian Escobar BravoiD· 2 shared Marco TonelliiD· 2 shared Takuma KumeiD· 2 shared Aaron A. HoskinsiD· 1 shared Abby A. McCanniD· 1 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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4 shared papersBiochemistry

Samuel E. ButcherORCID

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4 papers

Recent·Most cited

BiochemistryNature CommunicationsPeer-reviewedAug 12, 2026

TDP-43 controls RNA structure through high affinity lattice interactions

Rahul Vivek, Takuma Kume, Saeed Roschdi…·Samuel E. Butcher

This study shows TDP-43 binds to GU repeats with high affinity, prevents pUG fold formation, and reveals an interplay between RNA folding and protein recognition.

1 citation

humanexperimental assay

𝕏 PostBluesky

BiochemistryRNA BiologyPeer-reviewedMar 3, 2026

Sequence and ionic requirements of pUG fold quadruplexes

Saeed Roschdi, Takuma Kume, Riley J. Petersen…·Samuel E. Butcher

This study identifies sequence and ionic requirements for pUG fold RNA quadruplexes, showing flexibility in nucleotide substitutions and specific ion dependence.

5 citationstop 2%

experimental assay

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BiochemistryNucleic Acids ResearchPeer-reviewedJul 19, 2025

The structure, folding kinetics and dynamics of long poly(UG) RNA

Riley J. Petersen, Rahul Vivek, Marco Tonelli…·Samuel E. Butcher

This study investigates the structure, folding kinetics, and dynamics of long poly(UG) RNAs, revealing a dynamic model for segmental register exchange and double pUG fold formation.

7 citations

C. eleganslong-read sequencing

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Molecular BiologyNature Structural & Molecular BiologyPeer-reviewedNov 1, 2022

An Atypical RNA Quadruplex Marks RNAs as Vectors for Gene Silencing

Saeed Roschdi, Jenny Jiacheng Yan, Yuichiro Nomura…·Samuel E. Butcher

The paper identifies a novel RNA quadruplex structure, the pUG fold, that drives gene silencing in C. elegans and is present in human non-coding RNAs.

66 citationstop 4%

C. eleganshuman

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