TDP-43 controls RNA structure through high affinity lattice interactions
Rahul Vivek, Takuma Kume, Saeed Roschdi, M. Thomas Record, Aaron A. Hoskins, Samuel E. Butcher
This study shows TDP-43 binds to GU repeats with high affinity, prevents pUG fold formation, and reveals an interplay between RNA folding and protein recognition.
Nature Communications · Aug 12, 2026Peer-reviewedBiochemistry