Yann Humeau

The paper characterizes a VGLUT1 knock-down mouse model and finds that reduced VGLUT1 expression does not significantly affect quantal size or frequency of glutamate release.

This study investigates the role of hippocampal synaptic plasticity in memory consolidation during ripple activities, finding that it is essential during consolidation but not encoding or recall.

This study shows that AUTS2 gene dosage affects synaptic AMPA receptors through the AUTS2-TTC3-AKT-mTORC1 pathway, leading to behavioral and cognitive impairments in mice.

This study uses a knock-in mouse model to monitor and manipulate AMPA receptor mobility, showing its role in synaptic plasticity and memory formation.

This study investigates a missense Fmr1 mutation in mice, showing increased spine density, synaptic defects, and cognitive deficits linked to Fragile X syndrome.

The paper shows that frontal association cortex pyramidal neurons integrate Gaussian noise and amygdala inputs non-linearly to promote fear learning.

The paper identifies a mechanism by which VGLUT1 increases synaptic vesicle clustering, reducing superpool size and spontaneous release frequency through interactions with endophilinA1 and intersectin1.

This study shows that impaired AMPA receptor surface diffusion contributes to synaptic plasticity and memory deficits in Huntington’s disease, and that tianeptine can restore these functions.