Tim J. Vickers

The paper shows ETEC protease EatA degrades human MUC2 mucin specifically, enabling bacterial infection by disrupting the intestinal mucus layer.

This study shows that parenteral vaccination with recombinant EtpA glycoprotein can protect against ETEC intestinal colonization in mice, with protection dependent on vaccination schedule and adjuvant type.

This study identifies key structural and glycosylation features of EtpA, an ETEC adhesin, and shows how antibodies target different epitopes to influence immune responses and pathogen-host interactions.

The paper shows that host-derived CEACAM-laden vesicles capture ETEC and its toxins, reducing pathogen load and neutralizing toxins during infection.