This study identifies mRNA stem-loops and their stability as key regulators of stop codon readthrough in Drosophila, refining computational predictions of this phenomenon.

bioRxiv · Nov 7, 2025 · PreprintMolecular Biology

Altered Glycolysis TCA Anaplerosis Axis Impairs Monocyte Migration and Trains Macrophage Polarization in Long-term Treated HIV Infection

Alejandra Escós, Anoop T. Ambikan, Sabrina Schulster, Sara Svensson Akusjärvi, Marco Gelpi, Siavash Mansouri, Prajakta Naval, Ronaldo Lira‐Junior, Vikas Sood, Andreas Dehlbæk Knudsen, Pratik P Pathade, Flora Mikaeloff, Julie Høgh, Magda Lourda, Jan Vesterbacka, , Ujjwal Neogi

The paper identifies metabolic reprogramming in HIV-treated individuals that impairs monocyte migration and promotes M2-like macrophage polarization, enhancing HIV susceptibility.

bioRxiv · Jan 15, 2025 · PreprintSystems Biology

p38γ and p38δ modulate innate immune response by regulating MEF2D activation

Alejandra Escós, Ester Díaz‐Mora, Michael J. Pattison, Pilar Fajardo, Diego González‐Romero, Ana Risco, José Martín-Gómez, Éric Bonneil, Nahum Sonenberg, Seyed Mehdi Jafarnejad, Juan José Sanz‐Ezquerro, Steven C. Ley, Ana Cuenda

This study shows that p38γ and p38δ regulate innate immune responses by modulating MEF2D phosphorylation and transcriptional activity in mice.

eLife · Jul 17, 2023Peer-reviewedMolecular Biology