Rajkumar Savai

This study shows that loss of the Y chromosome in lung adenocarcinoma causes epigenetic and transcriptomic changes that increase lineage plasticity and poor clinical outcomes.

This study uses machine learning to screen FDA-approved compounds for KRAS G12C and G12D inhibition, identifying potential drug candidates for further experimental validation.

SAME improves multimodal spatial omics integration by allowing topological disruptions during alignment, enhancing cell-type accuracy and revealing hidden biological insights.

The paper identifies metabolic reprogramming in HIV-treated individuals that impairs monocyte migration and promotes M2-like macrophage polarization, enhancing HIV susceptibility.

This study shows that targeting ADORA1 and PDE10A together improves PAH symptoms in animal models by increasing cAMP levels and reducing vascular remodeling.

This study shows that DNMT3A mutations in CHIP lead to metabolic changes in macrophages that drive inflammation, and targeting these changes can improve heart failure outcomes.