Caitlin M. Carroll

This study shows that Kir6.2-KATP channels regulate glycolytic flux, neuronal activity, and sleep-wake transitions by modulating lactate dynamics and metabolic stability.

The paper develops a method to collect hippocampal interstitial fluid extracellular vesicles (EVISF) and finds sex-dependent changes in microglial EV proteome related to Aβ pathology.

This study shows that acute hyper- and hypoglycemia disrupt the metabolic cooperation between glucose and lactate in the brain, affecting sleep-wake cycles.

This study shows that Kir6.2-KATP channels are necessary for hyperglycemia-induced increases in amyloid-beta and Alzheimer's pathology by regulating lactate transport and Aβ release.

This study shows that sulfonylureas reduce Alzheimer's pathology by targeting vascular KATP channels, decreasing amyloid-beta aggregation and improving vascular function in mice.