Author

David M. Renner

University of PennsylvaniaORCID 0000-0003-0548-3876Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Susan Reich WeissiD· 3 shared Nicholas A. ParentiiD· 2 shared Anthony R. FehriD· 1 shared Benjamin Aaron GarciaiD· 1 shared Chengjin YeiD· 1 shared Darrell N. KottoniD· 1 shared Edward E. MorriseyiD· 1 shared Erica KorbiD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersMicrobiology

Susan Reich WeissORCID

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3 papers

Recent·Most cited

MicrobiologyProceedings of the National Academy of SciencesPeer-reviewedApr 8, 2026

SARS-CoV-2 and MERS-CoV disrupt host protein synthesis via nsp1 with differential effects on the integrated stress response

Nicholas A. Parenti, Renee Cusic, David M. Renner…·Susan Reich Weiss

This study compares how SARS-CoV-2 and MERS-CoV nsp1 proteins affect host protein synthesis and the integrated stress response, revealing differential impacts on eIF2 phosphorylation and stress granule formation.

3 citationstop 1%

humanproteomics

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MicrobiologyVirusesPeer-reviewedJan 16, 2025

Betacoronaviruses Differentially Activate the Integrated Stress Response to Optimize Viral Replication in Lung Derived Cell Lines

David M. Renner, Nicholas A. Parenti, Nicole R. Bracci, Susan Reich Weiss

This study compares how three betacoronaviruses interact with the PERK pathway of the integrated stress response, showing differences in their reliance on eIF2 dephosphorylation for replication.

7 citations

humanproteomics

𝕏 PostBluesky

GeneticsbioRxivPreprintNov 10, 2021

SARS-CoV-2 ORF8 encoded protein contains a histone mimic, disrupts chromatin regulation, and enhances replication

John Kee, Samuel Thudium, David M. Renner…·Erica Korb

5 citations

humanproteomics

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