Author

David Philip Lane

Karolinska InstitutetORCID 0000-0003-0551-3545Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:zebrafish· 1

Frequent Co-Authors

Dilraj LamaiD· 1 shared Filip MihaličiD· 1 shared Jason N. BermaniD· 1 shared Kim KobariD· 1 shared Lars BräutigamiD· 1 shared Martin KrkoškaiD· 1 shared Pavitra KannaniD· 1 shared Sania Kheder· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperPharmacology & Toxicology

Dilraj LamaORCID

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1 paper

Recent·Most cited

A stapled peptide inhibitor of MDM2 enables pharmacological activation of p53 in zebrafish

Sania Kheder, Martin Krkoška, Filip Mihalič, Kim Kobar, Zdeněk Andrysík, Lars Bräutigam, Susanne Lindström, Jason N. Berman, David Philip Lane, Dilraj Lama, Pavitra Kannan

The paper demonstrates that sulanemadlin, a stapled peptide inhibitor of MDM2, specifically activates p53 in zebrafish without inducing apoptosis, enabling direct in vivo studies of p53 regulation.

bioRxiv · Mar 30, 2026 · PreprintPharmacology & Toxicology