Sebastian D. Mackowiak

This study uses temporal PRC2 degradation in embryoid models to reveal lineage-specific gene expression changes and the role of transcription factors in PRC2 loss responses.

The paper studies microRNA and target expression variation in mouse embryonic stem cells using genetic perturbation and single-cell RNA-seq, finding four co-expression groups and mixed effects on target variation.

This study shows PD-1 blockade during T cell priming promotes an intermediate-exhausted CD8 T cell state that supports durable anti-tumor immunity after surgery and metastatic challenge, better than effector or memory-like T cells.

The paper identifies and characterizes LNCSOX17, a lncRNA essential for human endoderm formation, showing its role in regulating transcriptome and differentiation.

SSAM-lite provides a lightweight, web-based tool for rapid, segmentation-free analysis of spatially resolved transcriptomics data, enabling broad accessibility without requiring computational expertise.

The paper identifies >80,000 gene pairs with intrinsic covariance in mouse embryonic stem cells, showing nuclear organization and protein interactions drive transcript covariances.

This study shows BRG1 affects alternative splicing by altering RNA binding factor interactions with RNA, with some effects independent of its ATPase activity.