Scott M. Williams

Local genetic correlation analysis of Alzheimer's disease and stroke implicates PHLPP1 as a shared locus in individuals of African ancestry

Disrupted Lipid Homeostasis as a Pathogenic Mechanism in ABCA7-Associated Alzheimers Disease Risk

This paper investigates the impact of an ancestry-specific ABCA7 deletion on lipid homeostasis in Alzheimer's disease, showing disrupted lipid regulation in neurons.

Concordance between male- and female-specific GWAS results helps define underlying genetic architecture of complex traits

The paper uses sex-stratified analyses to explore genetic architecture of complex traits in mice and humans, finding high concordance in allelic effect directions and suggesting new methods for identifying biologically significant associations.

Alzheimer disease is (sometimes) highly heritable: Drivers of variation in heritability estimates for binary traits, a systematic review

This study reviews heritability estimates for late-onset Alzheimer's disease, showing significant variation across studies and highlighting the importance of population and methodological context.

Predicting risk of Alzheimer's disease using polygenic risk scores developed for Parkinson's disease

This study evaluates the predictive power of polygenic risk scores for Alzheimer's disease and Parkinson's disease, finding that filtered scores for both diseases are strongly predictive, with AD scores better predicting PD than vice versa.

Evidence of epistasis in regions of long-range linkage disequilibrium across five complex diseases in the UK Biobank and eMERGE datasets

The paper identifies epistatic SNP-SNP interactions in long-range LD across five diseases using UK Biobank and eMERGE data, finding associations involving conserved genes and essential genes.

Genetic effects on the timing of parturition and links to fetal birth weight

This study identifies genetic loci associated with gestational duration and preterm delivery, showing maternal and fetal genetic effects and antagonistic pleiotropy with birth weight.

Tuberculosis severity associates with variants and eQTLs related to vascular biology and infection-induced inflammation

This paper identifies genetic variants and eQTLs associated with TB severity, linking them to vascular biology and inflammation, using GWAS and eQTL analyses in TB patients.

Impact of natural selection on global patterns of genetic variation, and association with clinical phenotypes, at genes involved in SARS-CoV-2 infection.

The paper examines genetic variation and natural selection at SARS-CoV-2 host genes in diverse populations and links selected variants to clinical phenotypes in COVID-19.

Genetic study of late-onset neonatal sepsis reveals significant differences by sex

This study identifies genetic risk factors for late-onset neonatal sepsis, finding sex-specific associations and significant SNP-sex interactions.

A novel mapping strategy utilizing mouse chromosome substitution strains identifies multiple epistatic interactions that regulate complex traits

This study uses mouse chromosome substitution strains to identify both additive and epistatic genetic loci influencing complex traits and gene expression.

Haplotype genetic score analysis in 10,734 mother/infant pairs reveals complex maternal and fetal genetic effects underlying the associations between maternal phenotypes, birth outcomes and adult phenotypes

The paper uses haplotype genetic scores in mother/infant pairs to show maternal and fetal genetic effects influence gestational duration, birth outcomes, and adult phenotypes.

Detection of complex genetic architecture using two-locus population differentiation: modeling epistasis

This paper introduces a method to detect epistasis in complex traits by analyzing population differentiation at two loci, identifying novel gene interactions in pigmentation, schizophrenia, and preterm birth.

Genome wide-association study identifies novel loci in the Primary Open-Angle African American Glaucoma Genetics (POAAGG) study

The paper identifies a novel POAG-associated SNP in African Americans using a genome-wide association study.

Widespread Inter-Chromosomal Epistasis Regulates Glucose Homeostasis And Gene Expression

The paper shows that inter-chromosomal epistasis significantly influences glucose homeostasis and gene expression in mice, often overriding additive genetic effects.