Leandro C. A. Cerchietti

This study identifies lipid-laden macrophages as an immunosuppressive niche in PCNSL, validated through spatial transcriptomics and mouse models, and shows SYK inhibition reverses their tumor-supportive activity.

The paper identifies H3 serine 28 phosphorylation as a mechanism driving chromatin derepression and immune cell fate transitions by disrupting repressive chromatin domains.

This paper designs and characterizes bivalent aptamer assemblies targeting CD19 and CD20, showing enhanced binding and functional properties for B-cell malignancies.

This study trains a variational autoencoder on metabolomics data to learn nonlinear latent representations and validates its generalizability across different disease cohorts.

This study evaluates the reproducibility of m6A peak detection and changes using MeRIP-seq and finds limited consistency across studies.